Identification of a Ligand-Binding Site on theStaphylococcus aureusDnaG Primase C-Terminal Domain
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منابع مشابه
Identification of a Ligand-Binding Site on the Staphylococcus aureus DnaG Primase C-Terminal Domain.
The interface between the DnaG primase C-terminal domain (CTD) and the N-terminal domain of DnaB helicase is essential for bacterial DNA replication because it allows coordinated priming of DNA synthesis at the replication fork while the DNA is being unwound. Because these two proteins are conserved in all bacteria and distinct from those in eukaryotes, their interface is an attractive antibiot...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2017
ISSN: 0006-2960,1520-4995
DOI: 10.1021/acs.biochem.6b01273